Science IP Search Services

CAS is committed to the global advancement of science through the dissemination of scientific information to promote research performed by individuals and teams of scientists.

With Science IP® you have access to 11 of the industry's most experienced scientists, researchers and patent specialists. Whether you are looking for more information on nucleic acids, trying to determine if your patent has been compromised by an unauthorized party or find a chemical substance that meets your structural requirements, Science IP will have the answer.

Science IP searchers work closely and iteratively with their clients to develop search strategies tailored to the client’s needs and budget. Searches that require comprehensiveness are conducted in multiple databases to take advantage of the unique indexing policies of database providers.

Review the types of chemical structure, sequence, and key word searches below for a more detailed look on the answers/analysis services Science IP can provide:

How to Request a Search from Science IP?

  1. Submit online search request (one-time registration to create a login ID)
  2. Submit search request form (PDF)


Search Type Definition/Clarification

Intellectual Property

This search is often performed to support a legal opinion that an unauthorized party is, or is not, using a patented technology without the permission of the individual or organization who owns it. Assignees will conduct these searches to protect their patented intellectual property. 

Prior Art 
The most general type of search normally associated with the patenting process. Results from this search will include patent and non-patent literature which is associated with the topic of interest. The term "Prior Art" is used to describe relevant documents that discuss or provide background on the particular topic. 

Instead of providing general information on a topic (see Prior Art search), this search provides focused, specific information that is most relevant to a particular topic. Normally associated with the patenting process, this type of search will typically include a current awareness component for ensuring that the latest information is available on the topic. 

Often associated with patent litigation, this search will attempt to discover "art" (either from patents or from non-patent information sources) that was available in the public domain prior to the priority filing date of a patent of interest. Patent owners or potential licensees will sometimes conduct this search to ensure that a particular piece of intellectual property will stand up to a validity challenge. This type of search can also be conducted by organizations looking to invalidate a patented invention that is blocking them from conducting business. 

Typically an inventor or assignee will conduct this search to support a legal opinion that the invention they are looking to patent is both novel and non-obvious to someone skilled in the art of that particular subject. This type of search is very specific to the exact technology that is potentially going to be patented and will look to discover patent and non-patent references that speak to whether the invention is novel and non-obvious. 

An organization will typically conduct this search to support a legal opinion that a product does not infringe a valid, in-force patent held within the country where the organization is planning to conduct business. The focus of a freedom-to-operate search is on what is claimed.

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Chemical Structure, Sequence, Key Word Searches

Chemical Structure 
The purpose of this search is to discover chemical entities that either exactly match or are similar to a chemical compound of interest. There are a number of different types of structure searches that can be conducted including:

  • Exact - Discovered compound exactly matches the query compound.
  • Family - Discovered compounds includes the exact compound, as well as its salts, hydrates, solvates, mixtures, stereoisomers, racemic mixtures, geometric isomers, tautomers, zwitterions, coordination compounds, charged compounds, radicals, radical ions, isotopes and polymers in which the structure is indexed as a monomer.
  • Substructure - Discovered compounds are encompassed by the structure query containing variables and/or optional substitution at defined positions.
  • Markush - Chemical compounds being queried are potentially contained within a collection of generic or prophetic compounds defined using variable functional groups, atoms, ring sizes, etc. Markush structures are generally associated with patent literature.
  • Fragmentation - Query molecule is defined as the sum of its individual pieces or fragments and discovered compounds will contain the same collection of fragments but not necessarily connect in the same way that the query molecule was connected (i.e., functional groups, types of ring systems, etc.).

Chemical structures can also be discovered by other means including searching by molecular formula, CAS Registry Number, ring size and other chemical attributes. This search is often referred to as a dictionary search. 

Sometimes also referred to as a nucleic acid or amino acid search, the purpose of this search is to discover extended amino acid (peptides and proteins) or nucleic acid (genes) sequences that either exactly match or are similar to a sequence of interest. There are a number of different types of sequence searches that can be conducted including:

  • Exact - Discovered amino or nucleic acid sequence exactly matches the query sequence.
  • Subsequence - Discovered amino or nucleic acid sequence(s) completely encompasses the query sequence but may also contain additional amino or nucleic acid segments.
  • Homology - Discovered sequences are retrieved based on how much similarity they have to the query sequence. Computer algorithms are used to provide a score of how similar one sequence is to another.

Key Words 
If a topic, author name, assignee, or organization is provided this search will supply information on the available documents associated with this query. This search can be customized to include database records from patents, books, journal articles, dissertations and other types of data as required by the customer. A key word search includes text terms, patent classification codes and database producers’ value-added indexing.

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Additional Search Options

Connection Tables 
Connection Tables are how chemical structures are represented and stored in the CAS REGISTRYSM database. Up to 200,000 Connection Tables can be ordered in bulk from Science IP for individual or multiple project use within an organization. A project is defined as work on a specific question of scientific import to the organization. An example would be a project involving the design of JNK kinase inhibitors. Use of Connection Tables supplied by Science IP is limited to internal use only and subject to CAS Information Use Policy guidelines. Redistribution is strictly prohibited. The customer must provide the chemical substance name or CAS RN, either of which must be in a machine readable format (one per line). The chemical name must match a chemical name synonym found in REGISTRY. An attempt will be made to search for names which are not in REGISTRY if the customer agrees. Connection Table output can be provided in the following Structure File Formats: SD file, MOL file or SMILES strings. 

Current Awareness Alerts 
When you are managing a project, determining if someone is infringing your patent, monitoring the on-going patentability of your product, or determining your Freedom-to-Operate/Practice on an idea, the information you have can become outdated within a week of your search. New information, which may dramatically alter your ability to conduct business, is published on a weekly or even daily basis. In order to stay up to date on the latest knowledge on your topic of interest, it is important to have a source of updated information. Current awareness searches can be established so that your organization is continually kept updated on new, pertinent information as it becomes available. You can receive updates whenever new information on your topic of interest is published in the scientific literature or when a new, related patent/application is issued. 

CAS Registry Number Lookup 
When you have a chemical name and need to know the CAS Registry Number for the substance, this search will provide the number if available. If no CAS Registry Number is available Science IP can connect you with the scientists responsible within CAS who can assign one for you. 

CA Abstract Retrieval 
When you have a CAS accession number ("CAN") or some bibliographic information on a reference but need to retrieve the CAS abstract for a particular record, Science IP can provide this information for you. 

Reaction Information 
Science IP has access to a number of different databases containing chemical reaction data from both the patent and non-patent literature. If chemical structures are provided, this search will supply references that demonstrate how to perform a particular transformation or what products might be expected from a collection of starting materials. Reaction searching can be conducted using chemical functional groups when more general transformation, non-structurally specific data is required.

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Property, Regulatory, REACH Compliance

Property Data 
If a compound is provided, this search will supply information on the physical properties (such as melting point, vapor pressure, optical rotation, etc.) associated with this material. Conversely, if a property value or range is provided the chemical compounds that share that property can be discovered. 

Regulatory Data 
If a compound name or structure is provided, this search will identify if it is a controlled substance or is listed on any regulated compound lists. Regulatory lists searched include TSCA (USA), EINECS (Europe), ENCS (Japan) and DSL (Canada), among others. 

REACH Compliance 
REACH is Registration, Evaluation, Authorisation and Restriction of Chemicals. Science IP searchers are scientists with the skill and knowledge to help a company locate the substance and property data required to comply with the strict REACH regulations. If your company manufactures, imports or uses chemicals in the European Union, you may have to complete a REACH registration. The REACH regulation focuses exclusively on "substances." To ensure a properly working REACH system, unambiguous substance identification is essential.

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Science IP Sample Search Reports

Sample Sequence Search Report (PDF) 
Sample Structure Search Report (PDF) 
Sample Text Search Report (PDF) 

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